2024 AD. Currently we are living in a dream world , where weight loss requires no Surgery (Bariatric), Fad diets and strict gym-routine . The introduction of drugs like Wegovy and Mounjaro has reshaped the possibilities for those facing persistent challenges in shedding excess weight through conventional methods of diet and exercise alone.
The requirement for weekly injections, however, causes a noticeable inconvenience for some individuals despite the remarkable effectiveness of these drugs. Despite the fact that these injections are often very small, nearly invisible, and cause only minor discomfort, those who are averse to needles may be discouraged by the prospect of administering self-injections.
Does there exist an oral alternative, a pill to take instead of injections, to address this issue?
Enter Rybelsus, an oral medication that shares the same active ingredient as Wegovy — semaglutide. A miracle oral drug for weight loss now available in india .
Uses of Rybelsus:
Rybelsus is primarily used to treat type 2 diabetes.
It is an oral glucagon-like peptide-1 (GLP-1) receptor agonist.
How much Weight Loss is possible with Rybelsus?
Weight Loss Results:
Participants on the highest standard dose of 14 mg of oral semaglutide lost an average of 4.4 kg (less than 5% of their body weight) after 12 weeks. At that dose, participants lost over 17% of their initial body weight, on average in 52 weeks. In comparison, those who took a placebo only lost an average of 0.5 kg (0.5% of their body weight).
Mechanism of Action for Weight Loss:
Rybelsus works by mimicking the effects of GLP-1, which regulates blood sugar levels. It slows down digestion, reduces appetite, and may contribute to weight loss.
Onset of Action:
The onset of action may vary, but noticeable effects on weight loss may take a couple weeks.
Side Effects of Rybelsus:
Common side effects associated with Rybelsus comprise:
Nausea
Vomiting
Decreased appetite.
Abdominal pain
Diarrohea. It’s important to note that ,side effects tend to be the worst when you first start taking it and usually get better with time. Other rare, serious side effects to be aware of include an increased risk of:
Diabetic retinopathy
Pancreatitis
Acute kidney injury
Allergic reaction
Interactions:
Rybelsus may interact with other medications, especially those affecting the gastrointestinal system. Consult with a healthcare professional to discuss potential interactions.
Warnings:
Rybelsus is not recommended for people with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
It carries a boxed warning regarding the risk of thyroid C-cell tumors.
Contraindications:
Multiple endocrine neoplasia type 2 (tumors in glands).
Personal or family history of medullary thyroid carcinoma (a type of thyroid cancer).
Insulin-dependent diabetes.
Diabetic ketoacidosis.
Dosing of Rybelsus:
The recommended dosage for Rybelsus (generic name: semaglutide):
Treatment Initiation:
Begin with 3 mg of Rybelsus once daily for the first 30 days.
Note that this initial dosage is not intended for significant glycemic control but rather to help your body adjust to the medication and minimize side effects.
Gradual Increase:
After the initial 30 days, increase the dosage to 7 mg once daily.
If additional glycemic control is needed, the dosage can be further increased to 14 mg once daily.
However, taking two 7 mg tablets to achieve a 14 mg dosage is not recommended.
Administration Instructions:
Take Rybelsus at least 30 minutes before consuming your first meal, beverage, or other oral medications of the day.
Use no more than 4 ounces of plain water when taking Rybelsus.
Swallow the tablets whole; do not split, crush, or chew them.
Switching from OZEMPIC:
Patients on RYBELSUS 14 mg can transition to OZEMPIC subcutaneous injection 0.5 mg once weekly.
Patients on once-weekly OZEMPIC 0.5 mg can switch to RYBELSUS 7 mg or 14 mg.
Remember to consult your healthcare provider for personalized guidance and adjustments based on your specific needs. 🌿
Alternatives to Rybelsus for Weight Loss:
While Rybelsus is primarily used for diabetes management, alternative weight loss medications may include other GLP-1 receptor agonists :
injectable semaglutide, sold as Wegovy and Ozempic.
2. injectable liraglutide, marketed as Saxenda and Victoza.
3. injectable dulaglutide , available as Trulicity and Applevent .
or other oral medications are FDA-approved for weight loss.
These include:
Qsymia (phentermine/topiramate)
Contrave (naltrexone/bupropion)
Xenical, Alli (orlistat)
Kilfat (cetilistat )
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