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Hashimoto's disease is an autoimmune disorder that affects the thyroid gland, which plays an important role in managing many of the functions of the body. Also known as chronic lymphocytic thyroiditis, Hashimoto's disease is the most common cause of hypothyroidism or an underactive thyroid. If the thyroid gland is not active enough, it does not make enough thyroid hormone to meet the body's needs and causes certain functions of the body to slow down. As a result of Hashimoto's disease, functions such as heart rate, brain function, and the rate that the body converts food into energy, all slow down. Women are more likely than men to develop this condition. Left untreated, Hashimoto's disease may cause a variety of health complications.
Causes of Hashimoto's Disease
Hashimoto's thyroiditis is an autoimmune disorder, which means the body's immune system mistakenly attacks healthy cells and tissues in the body. In the case of Hashimoto's thyroiditis, the immune system attacks the thyroid gland, causing inflammation and damage to the gland. The exact cause of Hashimoto's thyroiditis is not fully understood, but it is believed to be a combination of genetic and environmental factors. Some of the factors that may contribute to the development of Hashimoto's thyroiditis include:
Genetic predisposition
Environmental triggers such as viral infections, iodine intake, and toxins
Hormonal imbalances such as estrogen dominance
Nutritional deficiencies such as selenium, zinc, and vitamin D
Research has also suggested that excessive iodine consumption may trigger thyroid disease in certain people.
Symptoms of Hashimoto's Disease
Symptoms of Hashimoto's Thyroiditis:
The symptoms of Hashimoto's thyroiditis can vary from person to person and may develop slowly over time. Some of the common symptoms of Hashimoto's thyroiditis include:
Fatigue
Weight gain
Intolerance to cold
Constipation
Dry, thinning hair
Dry skin
Depression
Slowed heart rate
Poor memory
Joint and muscle pain
Heavy and irregular menstrual bleeding
Difficulty getting pregnant
In some cases, patients with Hashimoto's thyroiditis may present with transient hyperthyroidism, called Hashitoxicosis, which is caused by the destruction of the thyroid follicles and excess release of the thyroid hormone. However, as the disease progresses, the predominant symptomatology is of hypothyroidism.
Diagnosis of Hashimoto's Disease
Diagnosis of Hashimoto's Thyroiditis:
Hashimoto's thyroiditis can be diagnosed using one of the following methods:
Physical exam – enlargement of the thyroid gland or goiter.
Blood test – usually elevated TSH, and low thyroid hormones (fT3, fT4). However, at earlier stages of Hashimoto's, most thyroid markers can appear within the normal range, but the antibodies are elevated, such as anti-thyroid peroxidase (TPO) and anti-thyroglobulin (TG) antibodies. You can have high antibodies for about a decade before other thyroid markers become abnormal. Thus, it is important to address the autoimmune picture and slow down the destruction of the thyroid gland before bigger problems manifest.
Ultrasound – enlarged thyroid
Fine Needle Aspiration Cytology (FNAC) – showing infiltration of immune cells in the thyroid gland.
Treatment of Hashimoto's Disease
Hashimoto's Thyroiditis Treatment
Hashimoto's thyroiditis is a chronic disease, and treatment is aimed at managing the symptoms and slowing the progression of the disease. The standard treatment for hypothyroidism caused by Hashimoto's thyroiditis is thyroid hormone replacement therapy. This involves taking a daily dose of synthetic thyroid hormone, such as levothyroxine (Thyronorm), which is identical to the hormone produced by the thyroid gland.
In addition to thyroid hormone replacement therapy, there are a few other treatment options that may be helpful for managing Hashimoto's thyroiditis. These include:
Diet and Lifestyle Changes: Some people find that dietary changes, such as avoiding gluten or reducing sugar intake, can help improve their symptoms. Exercise and stress reduction techniques, such as meditation or yoga, may also be helpful in managing symptoms.
Nutritional Supplements: Some people may benefit from taking nutritional supplements, such as selenium or iodine, which can help support thyroid function.
Anti-Inflammatory Medications: In some cases, nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, may be helpful in reducing inflammation in the thyroid gland.
Immunosuppressive Therapy: In rare cases, immunosuppressive medications, such as corticosteroids or methotrexate, may be necessary to manage severe autoimmune symptoms.
Hashimoto's Thyroiditis vs Hypothyroidism
Hashimoto's thyroiditis is an autoimmune disease that can lead to hypothyroidism, which is a condition where the thyroid gland does not produce enough thyroid hormone. However, not all cases of hypothyroidism are caused by Hashimoto's thyroiditis. Other causes of hypothyroidism include thyroid surgery, radiation therapy, and some medications.
The main difference between Hashimoto's thyroiditis and hypothyroidism is that Hashimoto's is an autoimmune disease, while hypothyroidism can have a variety of causes. In addition, Hashimoto's can sometimes cause transient hyperthyroidism, while hypothyroidism is characterized by a lack of thyroid hormone production.
Is Hypothyroidism an Autoimmune Disease?
While Hashimoto's thyroiditis is an autoimmune disease that can lead to hypothyroidism, not all cases of hypothyroidism are caused by autoimmune disease. However, autoimmune thyroid disease is the most common cause of hypothyroidism
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